Pest Growth Regulators


Pest Growth Regulators (PGRs) use synthetic replications of Pest hormones. PGRs have been used by pest control professionals to disrupt pest lifecycles and prevent pests from reaching full maturity. But the most recent technique to emerge is combining PGRs that prevent pests from maturing properly with PGRSs that prevent pests from developing cuticles, or exoskeletons, leaving them defenceless and vulnerable. This combination of PGRs can be effective in preventing re-infestation of pests such as cockroaches.
Pesticides with the growth regulating properties (PGR) may adversely affect insects by regulating or inhibiting specific biochemical pathways or processes essential for insect growth and development.
Some insects exposed to such compounds may die due to abnormal regulation of hormone-mediated cell or organ development. Other insects may die either from a prolonged exposure at the developmental stage to other mortality factors (susceptibility to natural enemies, environmental conditions etc) or from an abnormal termination of a developmental stage itself.
Pest growth regulators may come from a blend of synthetic chemicals or from other natural sources, such as plants.
Most PGRs have high potency against mosquitoes and other pest and vector species. In laboratory evaluations, their activities against mosquitoes range from 0.3 to 50 ppb.
Pyriproxyfen is one of the most effective juvenoid compounds, having an LCeo of less than I ppb). This level of activity is higher than that of some of the most active organophosphate larvicides. The chitin synthesis inhibitors also show high levels of activity, being effective in the range of 2-10 ppb these as well as other PGRs have been extensively studied against a variety of vectors and human pests.
The PGRs, in general, have a high margin of safety to fish, birds, other wildlife, and most aquatic nontarget organisms. Some PGRs are safer than others in this regard They also possess extremely low toxicity against humans.
These substances are classified as “Pest hormone mimics’’ or “Pest growth regulators’’ (PGRs) owing to their effects on certain physiological regulatory processes essential to the normal development of insects or their progeny. They are quite selective in their mode of action and potentially act only on target species. The rapid death of the insect through a failure of a key regulatory process to operate or function.
PGRs generally control insects either through regulation of metamorphosis or interference with
reproduction. Compounds developed to disrupt metamorphosis ensure that no reproductive adults are formed. Those that specifically interfere with reproduction may include the development of adults with certain morphogenetic abnormalities that reduce their reproductive potential. Adults may be sterile or possess abnormally developed genitalia, which hinders the mating process or the capacity to produce fertile offspring.
The action of PGRs, however, should not be confused with other synthetic Pesticides, such as organophosphates and carbamates, since these chemicals interfere with other physiological processes but do not regulate the development of normal insects. An IGR, therefore, does not necessarily have to be toxic to its target but may lead instead to various abnormalities that impair insect survival. Interestingly, most of the PGRs that have shown effectiveness against insect pests cause Pesticide regulation (e.g., EPA) emphasized the discoveries or synthesis of compounds (PGRs) that are specific to the target species and do not adversely (or at least minimally) affect beneficial and non-target species.

As a result, direct approaches for discovering selective Pesticides are being used, namely:

1) Synthesis of active analogues of biologically active compounds guided by the results of quantitative structure-activity relationship (QSAR) analyses;
2) Discovery of Pesticides from natural products, as well as a synthesis of their highly active analogues; and
3) Application of a bio-rational approach to design and synthesize Pesticides. Since the target sites of common Pesticides on insects and mammals are known to be similar, it is desirable to develop Pesticides whose primary target site does not exist in mammals for selective toxicity. PGRs may belong to this type of (selective) Pesticides and can be grouped according to their mode of action. Chitin synthesis inhibitors Substances that interfere with the action of insect hormones (i.e. JHs, ecdysteroids). The first chitin synthesis inhibitor introduced into the market as a novel insecticide was benzoylphenylurea Diflubenzuron It was considered a potent compound against larvae of common cutworm. Spodoptera litura and Cydia pomonella L. Some of the structural modifications (derivatives) of
the compound is more active than the parent compound.
Mode of action of chitin synthesis inhibitors (CSIs)
Most CSIs are primarily used as larvicides. Treated larvae develop until moulting, but fail to ease due to inhibition of the synthesis of the new cuticle, specifically, chitin biosynthesis. PGRs represent the newest of all approaches to operational and commercial insect control. Their species or stage-specificities that were higher than those of conventional Pesticides offer a good alternative for a selective insect pest control that is in harmony with existing IPM programs. PGRs generally have a good margin of safety for most non-target biota including invertebrates, fish, birds, and other wildlife. They are relatively safe for human beings and domestic animals.

Second-Generation Green Products

Until the past few years, much of the focus surrounding green products was from a public health perspective. But more and more, the demand for green products is shifting to eco-protection, a move related to the EPA’s focus on how materials affect the environment.
While green products have been on the market for some time, it’s the second-generation green products that are now emerging. These second-generation green products will have greater efficacy, better ingredients, and fewer downsides. For example, a first-generation insecticide may have contained plant essential oils, but it may have also been accompanied by an unpleasant smell. The second-generation insecticide will contain different proportions of the original ingredients or other materials to reduce the smell, while still being effective.

 Communication Tools

Technology is changing the way we communicate with the people and objects around us. When mobile data-capture devices were introduced, pest control professionals were able to capture real-time data about the location and nature of pest problems and then store it in a central database online that both facility managers and pest control professionals could access. This also made it simple to track multiple facilities and allowed for more timely corrective actions and more targeted pest-control treatments.
But what is the next big step in communication? Through video recording and real-time communication devices, such as Apple’s FaceTime application and the GoPro video, property managers can capture video of their particular pest problem and relay it directly to their pest management professional for instant diagnosis and corrective action recommendations. And vice versa, pest management professionals can use video to record and narrate inspections and leave a copy for the facility manager via email, or conduct a real-time video co-inspection with the customer if they are not able to be present at their facility during the inspection.
The pest control industry is only beginning to understand the opportunities to improve our business with mobile and social technology— but the possibilities are endless.

 Rodent Birth Control

For the past few years, pest management professionals have been using birth control for pest birds such as pigeons as a means of managing populations. Now the attention has turned to rodents. Though not yet on the market, rodent birth control may soon provide an effective way to control prolific breeders such as rats and mice without negatively impacting many non-target creatures. Be on the lookout for rodent birth control in the near future. ContraPest is a sustainable, non-lethal solution to the rodent problem. Rats love it!

Rats choose to consume ContraPest because of the high water, fat and sweet content of the bait. They return to the bait again and again even in the presence of high-value foods. Continued consumption of ContraPest leads to infertility in both male and female rats. There are no other adverse side effects. Rats, unlike mice, need to consume 10% of their body weight in water each day. ContraPest provides an attractive source of liquid. Once ingested, ContraPest is quickly metabolized by the rat and is environmentally neutral when excreted. ContraPest is specifically formulated for rats and does not affect other animal species or humans. It’s a sustainable and humane approach to pest control.

How it works
Our patented formulation causes both female and male rats to become infertile once they have consumed the effective dose. The active ingredient in females accelerates the rate at which ovarian follicles (egg structures) are depleted. Once these cells are gone, the animal cannot reproduce. In males, there is a marked reduction in the ability to fertilize eggs and, often, complete sterility. Otherwise, the animal lives out its normal 8 to 12-month lifespan without any observable side effects. It’s a truly humane approach that is also effective because it allows
populations to taper off naturally without a “rebound.” Orally self-administered and cost-effective Our non-lethal compound is placed in a liquid bait that brings rats back for seconds, thirds and more. They happily help themselves until over a few weeks both the males and the females have made themselves infertile. Otherwise, they continue to lead normal lives.
Rats need to consume at least 10% of their body weight in liquid every day, and our bait gives them an attractive source as they build up to the effective dose. Once ingested, our formula quickly becomes inactive. It is designed to be environmentally neutral when excreted. The SenesTech bait is specifically formulated for rats and does not affect other animal species or humans.

 Fly Baits

EndZone Insecticide Sticker One of the latest innovations in fly control is an insecticide sticker panel that can discreetly control a variety of fly species, including houseflies, blowflies, phorid flies, fruit flies, fungus gnats, and bottle flies. The small sticker is coated with insect food and an insecticide that has the ability to knockdown flies in just one minute upon contact. It does not release any fumes or odours once activated, and it can stay effective for up to seven months indoors. This new fly bait is designed to work in the variety of commercial settings and can be applied directly to areas where flies congregate, including windows, trash cans, under counters, behind
equipment, and near floor drains and food storage areas. In short, the industry is making a lot of advancements, which means good news for commercial properties fighting the battle against pests. Be sure to talk to your pest management professional about these emerging technologies and find out if they are appropriate for your